Among the side effects of steroids, we are the first to be affected
The gonadal axis, as mentioned earlier, is the essence of all steroid drugs we use On the other hand, it is exogenous sex hormones, which can dominate our muscles in the human body Human endocrine system has three branches: hypothalamus pituitary thyroid gland There are three major internal organs: gland axis; hypothalamus pituitary adrenal axis; hypothalamus pituitary gonad axis There is a clear division of labor among the secretory systems, and at the same time, they are interrelated and cooperative. The hypothalamus pituitary gonadal axis is a branch of the human body that controls the secretion of sex hormones. That’s it The hypothalamus secretes gonadotropin-releasing hormone (GnRH), and GnRH can stimulate the growth of hypothalamus Promote the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH) and Prolactin (PRL), which acts on the mammary gland, promotes the development of mammary gland and the growth of milk It’s produced. LH and FSH act on the ovaries of women and promote the secretion of progesterone (P) And estradiol (E2); in the male testis, promote testicular testosterone secretion （TTE）。
Of course, women’s ovaries also secrete a small amount of testosterone, and men’s testicles also secrete testosterone It secretes a small amount of P and TTE. Progesterone is an important factor in the early pregnancy Hormone, can make the female body temperature rise 0.3-0.5 degrees, E2 can promote the female reproductive system The development of sex and the appearance and maintenance of secondary sexual characteristics. At the same time, the synergistic effect of E2 and P in the uterus Intima, maintain the normal menstrual cycle of women.
TTE is to keep a person normal Sexual desire is a necessary hormone, which can promote the development of bone and muscle at the same time. This is the reason for sexual desire The reason why men are more generous than women is that men have more sexual desire than women The reason is that the TTE in men is much higher than that in women. In the blood PRL, P, E2, TTE content will have a feedback mechanism to reach the hypothalamus When the levels of these hormones in the blood increase or decrease, the hypothalamus receives this feedback After treatment, the secretion of GnRH will be adjusted in order to adjust the levels of LH, FSH and PRL in serum, Finally, the contents of P, E2 and TTE were adjusted. The whole process is simply like this. this Any functional disorder or disease in any part of the axis will affect the human sex Hormone secretion, there are a series of different clinical symptoms. But it’s more than that, The other two branches of the endocrine system, if dysfunctional, can also affect sex Hormone secretion of the gland axis, such as hyperthyroidism or hypothyroidism, can affect women’s body function Menstrual cycle and ovulation also affect men’s sperm maturation and sexual function. When we use exogenous hormones, our hypothalamic HPGA senses If the testosterone level in our body is too high, it will automatically stop or reduce self stimulation The secretion and operation of hormone, although the human body is intelligent, but for hormones, it is divided into two parts
There are no exogenous hormones and endogenous hormones, it will only determine that the human hormone level is sufficient Enough to stop our own hormone production when our testosterone level exceeds normal physiological level The amount of GnRH gonadotropin-releasing hormone secreted by the gonadal axis will also change with the range Should be reduced or even completely stopped, at this time, our body hormone flocculent chaos and data is not If it is reasonable, it will cause some problems. The most obvious one is the fertility problem that we often talk about Because the gonadal axis controls multiple hormones, when the endocrine system is in a mess, I The number of sperm in the body will be completely reduced or stopped, and the quality of sperm is poor This will cause fertility problems in the process of use.
In addition to the inhibition of exogenous hormones on the gonadal axis itself, other hormones also play an important role Effects on gonadal axis, such as excessive estrogen, can also affect gonadal axis twenty-eight How to judge the degree of inhibition of gonadal axis? The simplest one Judgment is to observe whether the size of the testis has shrunk. So what are the effects of steroid use on gonadal axis? gonad The most sensitive part of the axis is the multiple switch, which is inhibited and then stimulated to normal The secretion returned to normal, and then was inhibited after it returned to normal There will be complete desensitization, or even irreversible damage. But in general, Gonadal axis is still very strong, every time from the heavy pressure out of the shadow After a cycle of destruction, the body’s endocrine takes a long time to recover Normal, in a long period of time, the endocrine in the body may be very chaotic.
Post time: Apr-26-2021